Effects of crude ethanolic extract of Terminaliacatappa on the haematology parameters of red Sokoto goat sex perimentally infected with Trypanosomabruceibrucei

Authors

  • Jocelyn Iyowamhe Agbanu Department of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria
  • Mathew Chika Emere Department of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria
  • Yahaya Abdullahi Umar Department of Biological Sciences, Nigerian Defence Academy, Kaduna, Nigeria

Keywords:

Crude ethanolic extract, Terminaliacatappa, Trypanosomabruceibrucei, Red Sokoto goats

Abstract

The in-vivo activity of crude ethanolic extract of Terminaliacatappa stem bark administered orally and intraperitoneally on red Sokoto goats experimentally infected with Trypanosomabruceibrucei was investigated. 15 male goats weighing between 8kg to 10kg were randomly grouped into 5 groups with three goats per group. Goats in all the 5 groups were infected intravenously with T. b. brucei and after demonstration of parasitaemia Groups 1 to 4 were administered crude ethanolic extract of T.catappa as follows: 50mg/kg orally to group 1, 100mg/kg orally to group 2, 50mg/kg intraperitoneally to Group3and 100mg/kg intraperitoneally to group4) while group5 served as untreated control. All treatments were given for 7 days. Result of phytochemical analysis shows alkaloids, saponins, terpenoids and steroid, increase in weight, Packed Cell Volume (PCV) and Red Blood Cells (RBC) indices after treatment in treated groups were also observed. It was concluded that T. catappaethanolic extract given at a dose of 50 to 100mg/kg is effective and safe for the treatment of T. b. brucei infection in goats.

References

Abenga, J.N., Enwezor, F.N.C., Lawani, F.N.C., Ezebuiro, C., Sule, J., David, K.M., 2002. Prevalence of Trypanosomiasis in trade cattle at slaughter in Kaduna, Nigeria. Niger. J. Parasitol., 23, 107-110.

Adamu, S., Barde, N., Abenga, J.N., Useh, N.M., Ibrahim, N.D.G., Esiero, K.A.N., 2009. Experimental Trypanosomabrucei infection-induced changes in the serum properties of lipids and Cholesterol, and the clinical implication in pigs. J. Cell. Biol., 3, 015-020.

Alayande, L.B., Alayande, M.O., Mohammed, A.A., Adamu, T., Abubakar, U., Daneji, A.L., Ajagbonna, O.P., 2011. Efficacy of Terminalliaavincennioides and its combination with diminiazeneaceturate (Berenil) in rats experimentally infected with Trypanosomabruceibrucei. Sokoto J. Vet. Sci., 9(2), 11-34.

Allam, L., Ogwu, D., Agbede, R.I.S., Sackey, A.K.B., 2011. Haematological and serum biochemical changes in gilts experimentally infected with Trypaanosomabrucei. Veterinarskiarhiv, 81(5), 597-609.

Anosa, V.O., 1988. Haematological and biochemical changes in human and animal trypanosomiasis. Part 1. Revenue d’ Elevageet de Medecine Veterinaire des pays Tropiceux. 41(1), 65-78.

Anosa, V.O., Kaneko, J.J., 1983. Pathogenesis of Trypanosomabrucei infection in deer mice (Peromyscusmaniculata): Haematologic, erythrocyte biochemical, and iron metabolic aspects. Am. J. Vet. Res., 44, 639-644.

Baracos, V.E., Whitmore, W.T., Gale, R., 1987. The metabolic cost of fever. Canada. J. Physiol. Pharmacol., 65, 1248-1254.

Denbarga, Y., Ando, O., Abebe, R., 2012. Trypanossoma species causing bovine trypanosomosis in South Achefer District, Northern Ethiopia. J. Vet. Adv., (2), 108–113.

Edeoga, H.O., Okwu, D.E., Mbaebie, B.O., 2005. Phytochemical constituents of some Nigerian medicinal plants. Afr. J. Biotechnol., 4, 685-688.

Emmanuel, O.O., Agwu, I.U., Kyewalabe, E.K., 1999. Anaemia in experimental African trypanosomiasis. J. Protozool. Res., 9, 55-63.

Esievo, K.A.N., 1983. Trypanosome vivax, stock V953: inhibitory effect of type A influenza virus anti-HAV8 serum on in vitro Neuraminidase (Siliadase) activity. J. Parasitol., 69(3), 491-495.

Garba, S., Okeniyi, S.O., 2012. Antimicrobial activities of total alkaloids extracted from some Nigerian medicinal plants. J. Microb. Antimicrob., 4(3), 60-63.

Igweh, A.C., Onabanjo, A.O., 1989. Chemotherapeutic effects of Annona senegalensis on Trypanosom abruceibrucei. Ann. Trop. Med. Parasitol., 83, 527-534.

Jenkins, G.C., Mccorrie, P., Forsberg, C.M., Brown, J.C., 1980. Studies on the anaemia in rabbits infected with Trypanosomabruceibrucei. 1: Evidence or haemolysis. J. Compare. Pathol. (supplementary), 9, 1-7.

Losos, G.J., Ikede, B.O., 1972. Review of pathology of diseases of domestic and laboratory animals caused by Trypanosomacongolense, Trypanosome vivax, Trypanosomabrucei, Trypanosomarhodesiense and Trypanosomagambiense. Vet. Pathol., 9, 1-71.

Maina, C.I., Ng’wena, G.M., Mwaniki, D.M., Oucho, A.O., 2013. Histopathological effects of Trypanosom abruceibrucei infection on the master circadian rhythm pacemaker in rats, 13.

Malafaia, G., Talvani, A.J., 2011. Nutritional status driving infection by Trypanosomacruzi, lessons from experimental animals. J. Trop. MED., doi: 10. //55/2011/981879.

Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., Nnamdi, A., 2008. Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotechnol., 7(11), 1630–1636.

Mare, C.J., 2008. African Animal Trypanosomiasis. Hhtp://www.vet.uga.edu/VPP/gray_book02/fad. Accessed 15/07/2009.

Mc Corrie, P., Jenkins, G.C., Brown, J.L., Ramsey, C.E., 1980. Studies on the anaemia in rabbits infected with Trypanosomabruceibrucei, 2: Haematological studies on the role of the spleen. J. Compar. Pathol., 90, 123-137.

Mellors, A., Samad, A., 1989. The acquisition of lipid by African trypanosomes. Parasitology today. 5(8), 239-243.

Omotainse, S.O., Edeghere, H., Omoogum, G.A., Elhassan, E.O., Thompson, G., Igweh, C., Ukah, J.A.C., Ikenga, M.A., Halid, I., 2000. The prevalence of animal Trypanosomiasis in Konshisha local government area of Benue state, Nigeria. Isr. J. Vet. Sci., 55(4), 142-144.

Pathak, A.K., 2009. Effect of Trypanosoma species on nutritional status and performance of livestock. Vet. World., 2(11), 435-438.

Rocha, G., Martins, A., Gama, G., Brandao, F., Atouguia, J., 2004. Possible cases of sexual and congenital transmission of sleeping sickness. The Lancet 363 (9404), 247. Doi: 10,1016/S0140-673(03)15345-7. PMID 14738812.

Shuaibu, M.N., Wuyep, P.T.A., Yanagi, T., Hirayama, K., Ichinose, A., Tanaka, T., Isao, T.T., 2008. Trypanocidal activity of extracts and compounds from the stem bark of Anogeissusleiocarpusand Terminaliaavincennioides. Parasitol., 102(4), 697-703.

Sim, D.S.M., 2015. Drug administration. Spriger international publication, Switzerland in pharmacological basic of acute care. Chan, Y.K., Ng, K.P., Sim, D.S.M. (Eds). 27-36.

Sofowora, A., 1993. Medicinal plants and traditional medicine in Africa. Spectrum books limited, Ibadan, Nigeria. 1-10.

Umar, I.A., Ndidi, U.S., Mohammed, A., Anaedum, V.C., Zambuk, U.U., Umar, A.U., Bello, M.A., 2014. In vitroantitrypanosomal activity, antioxidant property and phytochemical Constituents of aqueous extracts of nine Nigerian medicinal plant. Asia. Pac. J. Trop. Dis., 4(5), 348-355.

World Health Organisation, 2012. Human African Trypanosomiasis (sleeping sickness). Fact sheet No. 259. http://www.int/mediacentre/factsheete/fs259/en/index.html

Published

2016-07-17

How to Cite

Iyowamhe Agbanu, J. ., Chika Emere, M. ., & Abdullahi Umar, Y. . (2016). Effects of crude ethanolic extract of Terminaliacatappa on the haematology parameters of red Sokoto goat sex perimentally infected with Trypanosomabruceibrucei. Scientific Journal of Veterinary Advances, 5(7), 97-104. Retrieved from http://sjournals.com/index.php/sjva/article/view/246

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