Correlation between serum levels of hepcidin and ferritin in patients with metabolic syndrome in R. Macedonia

Alberti, K.G.M.M., Eckel, R.H., Grundy, S.M., 2009. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; american heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation., 13(16), 1640–1645.

Bozzini, C., Girelli, D., Olivieri, O., 2005. Prevalence of body iron excess in the metabolic syndrome. Diabetes Care., 28, 2061–2063.

Cook, J.D., Flowers, C.H., Skikne, B.S., 2003. The quantitative assessment of body iron stores. Blood., 101, 3359–3364.

De Carvalho,V. F., Bressan, J., Babio, N., 2013. Prevalence of metabolic syndrome in Brazilian adults: a systematic review. BMC Public Health., 18, 13, 1198.

Dongiovanni, P., Fracanzani, A.L., Fargion, S., 2011. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J. Hepatol., 55, 920–932.

Fernandez-Real, J.M., Lopez-Bermejo A., Ricart W. 2002. Cross-talk between iron metabolism and diabetes. Diabetes., 51, 2348–2354.

Festa, A., D’Agostino, R., Tracey, R.P., 2002. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes. Diabetes., 51, 1131–1137.

Gami, A.S., Witt, B.J., Howard, D.E., 2007. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J. Am. Coll. Cardiol., 13(4), 403–414.

Ganz, T., 2011. Hepcidin and iron regulation, 10 years later. Blood., 117, 4425–4433.

Gillum, R.F., 2001. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men: the Third National Health and Nutrition Examination Survey. Int. J. Obes. Rel. Metab. Dis., 25, 639 –645.

Halle, M., Konig, D., Berg, A., 1997. Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease. Atherosclerosis., 128, 235–240.

Istvan, S.V., Beverley, B., Adrian, K., 2007. Ferritin and Transferrin Are Associated With Metabolic Syndrome Abnormalities and Their Change Over Time in a General Population Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).Diabetes Care., 30 (7) 1795-1801.

Jehn, M., Clark, J.M., Guallar, E., 2004. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care., 27, 2422–2428.

Jehn, M.L., Guallar, E., Clark, J.M., 2007. A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Am. J. Epidemiol., 165, 1047–1054.

Jiang, R., Manson, J.E., Meigs, J.B., 2004. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA., 291, 711–717.

Liang, S., Oscar, H.. Franco, F.B.H., 2008. Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese. J. Clin. Endocr. Metab., 93(12), 4690-6.

Megan, J., Jeanne, M., Clark, E.G. 2004. Serum Ferritin and Risk of the Metabolic Syndrome in U.S. Adults Diabetes Care., 27(10) 2422-2428.

Moirand, R., Mortaji, A.M., Loréal, O., 1997. A new syndrome of liver iron overload with normal transferrin saturation. Lancet ., 349, 95–97.

Nemeth, E., Tuttle, M.S., Powelson, J., 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Sci., 306(5704), 2090-3.

Nicola, M., Michela, T., Natascia C., 2012. Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study., Plos one., 8(6), 10.

Park, C.H., Valore, E.V., Waring, A.J., 2001. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem., 276, 7806–7810.

Pigeon, C., Ilyin, G., Courselaud, B., 2001. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem., 276, 7811–7819.

Rajpathak, S.N., Crandall, J.P., Wylie-Rosett, J., 2009. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta., 1790, 671–681.

Sam, A.H., Busbridge, M., Amin, A., 2013.Hepcidin levels in diabetes mellitus and polycystic ovary syndrome. Diabet Med., 30(12), 1495-9

Sheu, W.H., Chen, Y.T., Lee, W.J., 2003. A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men. Clin. Endocr., (Oxf)., 58, 380–385.

Sociedade Brasileira., 2005. Diretriz brasileira de diagnóstico e tratamento da síndrome metabólica. Arq. Bras Cardiol., 13, 3–28.

Toumainen, T.P., Nyyssonen, K., Salonen, R., 1997. Body iron stores are associated with serum insulin and blood glucose concentrations: population study in 1,013 eastern Finnish man. Diabetes Care., 20, 426–428.

Traglia, M., Girelli, D., Biino, G., 2011. Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations. J. Med. Genet., 48, 629–634.

Tuomainen,T.P., Nyyssonen, K., Salonen, R., 1997.Body iron stores are associated with serum insulin and blood glucose concentrations. Diabetes Care., 20, 426–428.

Williams, M.J., Poulton, R., Williams, S., 2002. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis., 165, 179–184.