Histidine rich protein 2 performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria

Authors

  • Chika Okangba Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Charles J. Elikwu aDepartment of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria. bDepartment of Medical Microbiology & Parasitology, Babcock University Teaching Hospital, Nigeria
  • Emmanuel O. Shobowale aDepartment of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria. bDepartment of Medical Microbiology & Parasitology, Babcock University Teaching Hospital, Nigeria
  • Opeoluwa Shonekan Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Victor Nwadike Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Babatunde Tayo Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Azubuike C. Omeonu Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Bibitayo Faluyi Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Chiamaka Meremikwu Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Oyindamola Falade Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Demilade Osoba Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Tolulope Binuyo Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria
  • Akinboboye Olutosin Department of Medical Microbiology & Parasitology, Ben Carson School of Medicine, Babcock University, Nigeria

Keywords:

Malaria, Rapid diagnostic test, Microscopy, Ilishan-Remo, Nigeria

Abstract

Malaria rapid diagnostic test (RDT) is an antigen capture assay that enables rapid diagnosis of malaria without the need for electricity or highly skilled technicians. Though potentially useful, its adoption needs to be guided by local test sensitivity. This study evaluated the diagnostic performance of a commercially available RDT among 200 febrile patients (aged 2months to 72 years) in Ellison, Ogun State Nigeria. It was a prospective observational study conducted at the Babcock Teaching Hospital (BUTH) between February and June, 2015. Finger prick blood samples were collected from each of the patients (day 0) and immediately tested for P. falciparum malaria by both Giemsa microscopy and rapid diagnostic test (RDT). The prevalence of malaria among the study cohort was 15.0% by microscopy and 17.0% by RDT. The RDT had a sensitivity of 83.3% and specificity of 94.7%; with positive and negative predictive values of 73.5% and 96.9% respectively. The diagnostic performance of the RDT in this study was good. Hence, it is recommended as an alternative method for diagnosis of malaria, especially when microscopy is not feasible.

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2016-01-19

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Okangba, C. ., Elikwu, C. J. ., Shobowale, E. O. ., Shonekan, O., Nwadike, V. ., Tayo, B. ., Omeonu, A. C. ., Faluyi, B. ., Meremikwu, C. ., Falade, O. ., Osoba, D. ., Binuyo, T. ., & Olutosin, A. . (2016). Histidine rich protein 2 performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria. Scientific Journal of Pure and Applied Sciences, 5(1), 339-350. Retrieved from http://sjournals.com/index.php/sjpas/article/view/255

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Copyright (c) 2020 Chika Okangba, Charles J. Elikwu, Emmanuel O. Shobowale, Opeoluwa Shonekan, Victor Nwadike, Babatunde Tayo, Azubuike C. Omeonu, Bibitayo Faluyi, Chiamaka Meremikwu, Oyindamola Falade, Demilade Osoba, Tolulope Binuyo, Akinboboye Olutosin

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