Genetic mice models of Parkinson’s disease

Authors

  • R. Bolaños-Jiménez Neuroscience and Biotechnology Laboratory, School of Medicine, Universidad Panamericana, México DF, México
  • C. Escamilla-Ocañasb Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza García, NL, México
  • H. Martínez-Menchacab Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza García, NL, México
  • G. Rivera-Silva Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza García, NL, México
  • O. F. Chacon-Camacho Department of Genetics-Research Unit, Institute of Ophthalmology “Conde de Valenciana” Mexico City, Mexico
  • J. D. Carrillo-Ruíz Department of Neuroscience and Psychophysiology, Universidad Anahuac, Mexico City, Neurosurgery Clinic of Spasticity, Service Functional Neurosurgery and Radiosurgery Hospital General de México O.D

Keywords:

Parkinson's disease, Dopaminergic neurons, Neurodegeneration, Substantia nigra pars compacta, Gene, Mutation

Abstract

The loss of dopaminergicneurons in the substancia nigra pars compacta leads to the characteristicsymptoms of Parkinson's disease (PD), whose Lewy bodies is a pathologic signalmost always found. Various monogenic forms account for a minority of cases ofPD, but have provided crucial insight into disease mechanism. However,genetically faithful models have not been exposed to putative toxicants in amanner that is clearly relevant to human exposures, and most of studies haveused conventional genetically modified animals and convenient dosing paradigms.Better translation between preclinical, neuropathologic animal model and,clinical research would be important for future clinical trials.

References

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Published

2013-03-27

How to Cite

Bolaños-Jiménez, R. ., Escamilla-Ocañasb, C. ., Martínez-Menchacab, H. ., Rivera-Silva, G. ., Chacon-Camacho, O. F. ., & Carrillo-Ruíz, J. D. . (2013). Genetic mice models of Parkinson’s disease. Scientific Journal of Medical Science, 2(3), 45-47. Retrieved from http://sjournals.com/index.php/sjms/article/view/1342

Issue

Vol. 2 No. 3 (2013): March

Section

Short Communication

License

Copyright (c) 2013 R. Bolaños-Jiménez, C. Escamilla-Ocañasb, H. Martínez-Menchacab, G. Rivera-Silva, O. F. Chacon-Camacho, J. D. Carrillo-Ruíz

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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