Nephrosterinic acid inhibits the growth of murine malignant pleural sarcoma cells in vitro

Authors

  • Apee Nonjah Damelolah Public Health Institute, Niamey, Niger
  • S. A. Vivic Damelolah Public Health Institute, Niamey, Niger
  • Jibbahday A. L. Joejoe Damelolah Public Health Institute, Niamey, Niger

Keywords:

Nephrosterinic acid, Murine malignant

Abstract

We test the effects of Nephrosterinic acid, secondary metabolite of the lichen Solenospora liparina, on the growth of murine malignant pleural sarcoma cells in vitro. We find that Nephrosterinic acid is a potent inhibitor of growth. We also find that Nephrosterinic acid increases sensitivity of cells to radiation, and this effect is significant at a radiation intensity lower than the standard intensity of cancer radiotherapy. On the basis of this study, Nephrosterinic acid shows promise for combined-modality cancer treatment.

References

Baumann, M., Krause, M., Hill, R., 2008. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer, 8, 7, 545-554.

Prestwich, R. J., Shakespeare, D., Waters, S., 2007. The rationale and current role of chemoradiotherapy. J. Radiotherapy. Prat. 6, 11-19.

Kamb, A., Wee, S., Lengauer, C., 2007. Why is cancer drug discovery so difficult? Nat Rev Drug Discovery, 6, 115-120.

Boustie, J., Grube., 2005. Lichens: a promising source of bioactive secondary metabolites. Plant genetic resources: characterization and utilization, 3, 273-287.

Vermeulen, K., Van Bockstaele, D.R., Berneman, Z.N., 2003. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell proliferation, 36, 131-149.

Lawrey, J.D., 1986. Biological Role of Lichen Substances. The Bryologist, 89, 2, 111-122.

Published

2013-06-29

How to Cite

Nonjah, A. ., A. Vivic, S., & L. Joejoe, J. A. . (2013). Nephrosterinic acid inhibits the growth of murine malignant pleural sarcoma cells in vitro. Scientific Journal of Medical Science, 2(6), 100-104. Retrieved from http://sjournals.com/index.php/sjms/article/view/1332

Issue

Section

Original Article

Similar Articles

You may also start an advanced similarity search for this article.