MCP-1 (monocyte chemoattractant protein-1) concentrations in patients on hemodialysis.An observational study

Abstract

Monocyte chemoattractant protein-1 (MCP-1) is the main representative of chemokines, which are cytokines whose main function is to direct the migration of circulating leukocytes to sites of inflammation.The present study focuses on  the intra- and interdialytic MCP-1 changes in patients on hemodialysis.SUBJECTS – METHODS : We studied 76 stabled dialyzed patients (47 males / 29 females) and 24 healthy subjects.The treatment modalities which were applied were : regular haemodialysis (HD, n=34) and predilution haemodiafiltration (HDF, n=42) using synthetic high-flux dialysis membranes.Four blood samples were drawn (pre-hemodialysis, 2 hours, 4 hours and 44 hours after the beginning of the mean weekly dialysis session) and serum MCP-1 concentrations were measured using ELISA. RESULTS : MCP-1 levels were not found higher compared to control group (p=NS), but significantly changed over time (p<0.05).The following hemodialysis modality or the material of used dialysis membranes did not influence the observed changes of MCP-1 over time (p=NS). CONCLUSION : MCP-1 serum concentrations in stabled patients on permanent hemodialysis treatment were significantly changed over time independently on the following dialysis modality, despite the pre-dialysis MCP-1 mean value was similar to that of healthy subjects.