Epidemiology of hirsutism in Qassim Region, KSA

Authors

  • S. R. Ahmed Department of Obstetrics & Gynecology, Qassim College of Medicine, Saudia Arabia
  • A. A. Al Zolibani Department of Dermatology, Qassim College of Medicine, Saudia Arabia
  • A. A. Al Robaee Department of Dermatology, Qassim College of Medicine, Saudia Arabia
  • H. O. Hamed Department of Obstetrics & Gynecology, Qassim College of Medicine, Saudia Arabia
  • A. Settin Department of Pediatrics & Genetics, Qassim College of Medicine, Saudia Arabia

Keywords:

Genetic, Hirsutism, PCO, Idiopathic hirsutism

Abstract

Hirsutism is acommon clinical condition that usually has a benign course. A geneticabnormality causing hirsutism is supported by the observation that differentmembers of the same family are often affected.The goal of this study is toevaluate the genetic aspect of inheritance and consanguinity patterns ofhirsute cases in Qassim region, Saudia Arabia. A total 83 hirsute patients werestudied during one year duration. All patients underwent detailed history andthorough clinical evaluation. Ultrasonography and hormonal profiles wereperformed.The most common cause of hirsutism in this study was due topolycystic ovary (PCO) that was present in 52 patients (62.65%) followed byidiopathic hirsutism (IH) in 30 patients (36.14%) in addition to one case oflate onset congenital adrenal hyperplasia. Acne was encountered in 34 (65.38%)of cases of PCO and in 13(43.33%) of cases of IH. Positive family history andconsanguinity were encountered in 48(57.83%) and 49 (59.03%) casesrespectively. Our study suggested that hirsutism is a familial disorder.Inheritance pattern appeared to be possible particular from the maternalfollowed by the paternal side of the family.

References

Al-Robaee, A., Al-Zolibani, A., Al-Shobaili, H.A., Aslam, M., 2008. Update on hirsutism; Acta Dermatoven APA Vol 17, No 3.

Alvarez-Blasco, F., Botella-Carretero, J.L., San Millan, J.L., 2006. Prevalence & characteristics of PCOS in overweight and obese women. Arch. Intern. Med., 166, 2081-6.

Atallah, D.A., Usman, H.M., Riad, A.S., 2008. Hirsutism in Saudi females of reproductive age: a hospital –based study. Ann. Saudi. Med., 28(1), 28-32.

Ayhan, C.,Onder, E., Deniz, C.A., Ali, O., Metin, K., Gurkan, K., Bulent, K., 2011. Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women.Eur. J. Obst. Gyn. Rep. Bio., (154)167-171.

Barth, J.H., Catalan, J., Cherry, C.A., Day, A., 1993. Psychological morbidity in women referred for treatment of hirsutism. J. Psychosom. Res., 37, 615–619.

Carey, A.H., Chan, K.L., Short, F., White, D., Williamson, R., Franks, S., 1993. Evidence for a single gene causing polycystic ovaries and male pattern baldness, Clin. Endocrinol., (38) 653-658.

De Berker, D.A.R., Messenger, A.G., Sinclair, R.D., 2004. Disorders of hair. In: Burns T, Breathnach S, Cox N, Griffiths C,eds. Rook’s Textbook of Dermatology. Seventh ed. Oxford: Blackwell Sci.

Erkkola, R., Ruutiainen, K., 1990. Hirsutism: definitions and etiology. Ann. Med., 22, 99 -103.

Ferriman, D., Gallwey, J.D., 1961. Clinical assessment of body hair growth in women. J. Clin. Endocrinol. Metab., 21,1440–1441-1.

Gatee, OB., al Attia, H.M., Salama, I.A., 1996. Hirsutism in the United Arab Emirates: a hospital study. Postgrad. Med. J., 72, 168 -171.

Habib, A., Mir-Hadi, A.J., et al., 2007. Clinical presentation and etiologic factors of hirsutism in premenopausal Iranian women; Arch. Iranian. Med., 10(1), 7-13.

Hartz, A.J., Barboriak, P.N., Wong, A., Katayama, K.P., Rimm, A.A., 1979. The association of obesity with infertility and related menstrual abnormalities in women. Int. J. Obesity., 3, 57-73.

Hatch, R., Rosenfield, R.L., Kim, M.H., Tredway, D., 1981. Hirsutism: implications, etiology, and management. Am. J. Obstet. Gynecol., 140, 815-83.

Hunter, M.H., Carek, P.J., 2003. Evaluation and treatment of women with hirsutism. Am. Fam. Physician., 67, 2565-2572.

Melissa, K.M., Ricardo, A., 1999. Heritability and the risk of developing androgen excess; J. Steroid Biochemistry Molecular. Biology., (69) 261-268.

Mithal, A., Ammini, A.C., Godbole, M.M., Khurana, M.L., Raj, D., Karmarkar, M.G., et al., 1988. Late-onset adrenal hyperplasia in North Indian hirsute women. Horm. Res., 30, 1 – 4

Moncada, E., 1970. Familial study of hirsutism. J. Clin. Endocrinol. Metab., 31, 556-564.

Moran, C., Tapia, M.C., Hernandez, E., Vazquez, G., Garcia-Hernandez, E., Bermudez, J.A., 1994. Etiological review of hirsutism in 250 patients. Arch. Med. Res., 25, 311- 314.

O'Driscoll, J.B., Mamtora, H., Higginson, J., Pollock, A.K., Anderson, D.C., 1994. A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. Clin. Endocrinol (Oxf)., 41, 231 - 236.

Ricardo, A., Enrico, C., Marty, E.S., Idiopathic, h., Endocrine, R., 2000. 21(4), 347-362.

Rotterdam ASRM/ESHRE sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS. Fertil Steril 2004., 81, 19-25.

Zargar, A.H., Wani, A.I., Masoodi, S.R., Laway, B.A., Bashir, M.I., Salahuddin, M., 2002. Epidemiologic and etiologic aspects of hirsutism in Kashmiri women in the Indian subcontinent. Fertil. Steril.,77, 674 – 678.

Downloads

Published

2013-09-29

How to Cite

R. Ahmed, S. ., Al Zolibani, A. A. ., Al Robaee, A. A. ., O. Hamed, H. ., & Settin, A. . (2013). Epidemiology of hirsutism in Qassim Region, KSA. Scientific Journal of Medical Science, 2(9), 195-200. Retrieved from http://sjournals.com/index.php/sjms/article/view/1322

Issue

Vol. 2 No. 9 (2013): September

Section

Original Article

License

Copyright (c) 2013 S. R. Ahmed, A. A. Al Zolibani, A. A. Al Robaee, H. O. Hamed, A. Settin

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.