Incidence of malignancy in non toxic multi-nodular goiter an institutional experience
Keywords:
Multinodular Goiter, Incidence, Thyroid malignancyAbstract
The objective of the study is to determine the incidence of malignancy in non toxic multinodular goiter patients who underwent thyroid surgery in our institution. This is a prospective study carried out in the Department of general surgery, Liaquat University of Medical & Health Sciences Hospital Jamshoro, from January 2011 to December 2011. A total no. of 95 cases with clinical diagnosis as non toxic Multinodular goiter who underwent subtotal thyroidectomy were included in the study. Their biopsy specimen were sent to our university laboratory. The biopsy reports were collected in a week time and results were recorded. All the data was recorded on predesigned Performa. Out of 95 patients 7 (7.37%) patients were diagnosed as having malignancy on biopsy reports. Females (6 patients) were affected more commonly then male patients. Papillary carcinoma is the more commonest variant seen in 5 (71.4%) patients, follicular carcinoma in 1(14.3%) patient while Medullary carcinoma is also reported in 1(14.3%) patient. We conclude that the risk of malignancy in non toxic Multinodular Goiter is not to be under estimated, and a dominant nodule in Multinodular Goiter should be valued for thyroid cancer .
References
Alagic-Smailbegovic, J., Kapidzic, A., Sutalo, K., Resic, M., Hadzic, E., 2005. Surgical treatment of thyroid gland
disease. Med. Arh., 59,241–3.
Benzarti, S., Miled, I., Bassoumi, T., Ben Mrad, B., Akkari, K., Bacha, O., Chebbi, M.K., 2002. Thyroid surgery
(356cases), risks and complications. Rev. Laryngol. Otol. Rhinol., (Board) 123(1), 33-7.
DeGroot, L.J., Jameson, J.L., 2003. Endocrinol. Philadelphia, W. B. Saunders, Vol 2. 4th ed. 2001, pp.1541-66.
Giuffrida, D., Gharib, H., 1995. Controversies in the management of cold, hot and occult thyroid nodules. Am. J.
Med., 99,642-50.
Hanks, J.B., Thyroid., Townsend, C.M., Beauchamp, R.D., Evers, B.M., Mattox, K.L., 2004. (editors) In, Sabiston's
Text Book of Surgery 17th ed. Philadel phia. Saunders., 961–2.
Hanks, J.B., Thyroid., Townsend, C.M., Beauchamp, R.D., Evers, B.M., Mattox, K.L., 2004. (editors) In, Sabiston's
Text Book of Surgery 17th ed. Philadelphia, Saunders., 961–2.
Hossein, G., 1997. Changing concepts in the diagnosis and management of the thyroid nodules. End. Metabol. Clin.
N. Am., 26,777-800.
Kona, S., AL-Mohareb, A., 1988. the Surgery of goiter in Riyadh Armed Forces Hospital. Saudi. Med. J., 9, 617-21.
Larijani, B., Mohagheghni, M.A., Bastanghah, M.H., Mosavi-Jarrahi, A.R., Haghpanah, V., Tavangar, S.M., et al.,
Primary thyroid malignancy in Tehran-Iran. Med. Princ. Pract., 14,396-400.
Lopez, L.H., Herrera, M.F., Gamino, R., Gonzalez, O., Peraz- Enriquez, B., Rivera, B., et al., 1997. Surgical treatment
of multinodualr goitre at the Instituto Nacional de nutricion Salvador Zubiran [in Spanish]. Rev. invest. Clin.,
,644-7.
McCall, A., Jarosz, H., Lawrence, A.M., Paloyan, E., 1986. The incidence of thyroid carcinoma in solitary cold
nodules and in multinodular goitre. Surg., 100,1128-32.
McCall, A., Jarosz, H., Lawrence, A.M., Paloyan, E., 1986. The incidence of thyroid carcinoma in solitary cold
nodules and in Multinodular goiter. Surg., 100,1128-32.
Memon, W., Khanzada, T.W., Samad, A., Kumar, B., 2010. incidence of thyroid carcinoma in Multinodular goiters.
Rawal. Med. J., 35(1),65-7.
Mofti, A.B., Al Momen, A.A., Suleiman, S.I., Jain, G.C., Assaf, H.M., 1991. Experience with thyroid surgery in Security
Forces hospital. Riyadh. Saudi. Med. J., 12,504-6.
Prades, J.M., Dumollard, J.M., Timoshenko, A., Chelikh, L., Michel, F., Estour, B., et al., 2002. Multinodular goiter,
surgical management and histopathological findings. Eur. Arch. Otolaryngol., 259,217–21.
Qureshi, J.N., Muneer, A., Memon, A.S., Memon, S., Hammad, A., 2006. Malignancy in nodular goiter. J. Surg. Pak.,
(2),71–2.
Rugiu, M.G., Piemonte, M., 2009. Surgical approach to retrosternal goiter, Do we need sternotomy? Acta
otorhinolaryngologica Italica.., 29,331-38.
Sakoda, L.C., Horn-Ross, P.L., 2002. Reproductive and Menstural history and Papillary thyroid cancer risk. The San
Francisco bay are thyroid cancer study. Cancer Epidemol. Biomarkers Prev., 11(1),51-7.
Shah, S.H., Muzaffar, S., Soomro, I.N., Hassan, S., 1999. Morphological patterns and frequency of thyroid tumors. J
Pak. Med. Assoc., 49(6),131-3.
Sherman SI. Thyroid carcinoma. Lancet., 361,501-11.
Thomas, W.E.G., 2004. Neoplasm’s of thyroid gland (including the solitary nodule). Surg. Int., 64, 296–300.
Waqar, T., Ali, N., 2006. Cold thyroid nodule, A comparison of fine needle aspiration cytology with histopathology.
Profess. Med. J., 13(4),498-503.
Williams, E.D., 2003. Chernobyl, 15 years later, correlation of clinical, epidemiological and molecular outcomes.
Ann. Endocr., 64,72–5.
Wu, H.S., Young, M.T., Ituarte, P.H.G., D’Avanzo, A., Duh, Q.Y., Greenspan, F.S., et al., 2000. Death from thyroid
cancer of Follicular cell origin. J. Am. Coll. Surg., 191,600–6.
Zuberi, L.M., Yawer, A., Islam, N., Jabbar, A., 2004. Clinical presentation of thyroid cancer patients in PakistanAKUH Experience. J. Pak. Med. Assoc., 54(10),526-8.
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