TOXICITY AND ANALGESIC STUDIES OF LEAF METHANOLIC EXTRACT OF MAYTENUS SENEGALENSIS (LAM.) EXELL (CELASTRACEAE)

Authors

  • A. A. Murjanatu Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria
  • K. Y. Musa Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria
  • G. Ibrahim Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University, Zaria, Nigeria
  • M. G. Magaji Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University, Zaria, Nigeria

Keywords:

Toxicity, analgesic, methanolic extract, Maytenus senegalensis, Celastraceae, acetic acid-induced writhing, formalin induced pain

Abstract

The leaf methanolic extract of Maytenus senegalensis (Lam.) Exell was investigated for toxicity and analgesic effects. Acute toxicity was investigated via intraperitoneal route using mice and rats, analgesic activity was investigated using two models; acetic acid-induced writhing in mice and formalin induced pain in rats. The extract was determined to have LD (50) of 1264.91 mg/kg in both mice and rats. It significantly (0.001) inhibited acetic acid-induced writhes in mice at all doses administered (75, 150 and 300 mg/kg) in a dose dependent manner and significantly (0.01) inhibited formalin induced pain in rats, in a non-dose dependent manner. The inhibitory effect observed was higher in the extract compared to the standard used (piroxicam). The results obtained suggested the extract to be relatively toxic in both mice and rats with a dose dependent anti-nociceptive activity.

Published

2020-11-13

How to Cite

A. Murjanatu, A., Y. Musa, K., Ibrahim, G. ., & G. Magaji, M. (2020). TOXICITY AND ANALGESIC STUDIES OF LEAF METHANOLIC EXTRACT OF MAYTENUS SENEGALENSIS (LAM.) EXELL (CELASTRACEAE). Health, Safety and Environment , 3(2), 16-20. Retrieved from http://sjournals.com/index.php/hse/article/view/1532

Issue

Vol. 3 No. 2 (2015): February

Section

Original Article

License

Copyright (c) 2015 A. A. Murjanatu, K. Y. Musa, G. Ibrahim, M. G. Magaji

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.