A concomitant case of unilateral renal agenesis and unihorn uterus in a balb/c mouse

Authors

  • Leishangthem Geeta Devi Department of Pathology, AIIMS, New Delhi, India
  • Nittin Dev Singh Department of Veterinary-Pathology, COVS, GADVASU, Ludhiana, India
  • Harmanjit Singh Banga Department of Veterinary-Pathology, COVS, GADVASU, Ludhiana, India
  • Prashant Dattatray Gadhave Department of Veterinary-Pathology, COVS, GADVASU, Ludhiana, India

Keywords:

Mice, Kidney, Ureter, Uterine horn

Abstract

A case of unilateral renal agenesis and unihorn uterus in BalbB/C mice is discussed here. The post mortem examination conducted on naturally dead mice revealed absence of left kidney, ureter and left uterine horn which is rare condition in BalbB/C mice. Microscopically kidney, ureter and uterus did not show any significant histopathological alterations. Different etiologies might be related to such nonlethal genetic defect resulting in abnormal organogenesis.

References

Hardman, P., Kolatsi, M., Winyard, P.J., Towers, P.R. and Woolf, A.S., 1994. Branching out with the ureteric bud.

Exp. Nephrol. 2(4), 211-219.

Kamba, T., Higashi, S., Kamoto, T., Shisa, H., Yamada, Y., Ogawa, O., and Hiai, H., 2001. Failure of ureteric bud

invasion - A new model of renal agenesis in mice. Am. J. Patho. 159(6), 2347-2353.

Kreidberg, J.A., Sariola, H., Loring, J.M., Maeda, M., Pelletier, J., Housman, D. and Jaenisch, R., 1993. WT-1 is

required for early kidney development. Cell. 74, 679–691.

Luna, L.G., 1968. Manual of Histochemical Staining Methods of Armed Forces Institute of Pathology, Third ed.

McGraw hill Book Co. New York, pp. 32.

Padmanabhan, R., 1998. Retinoic acid-induced caudal regression syndrome in the mouse fetus. Reprod. Toxicol.

(2), 139-151.

Pritchard-Jones, K., Fleming, S., Davidson, D., Bickmore, W., Porteous, D., Gosden, C., Bard, J., Buckler, A., Pelletier,

J., Housman, D., Van Heyningen, V., and Hastie, N., 1990. The candidate Wilms' tumour gene is involved in

genitourinary development. Nature. 346, 194–197.

Rothman, K.J., Moore, L.L., Singer, M.R., Nguyen, U.T., Mannino, S. and Milunsky, A., 1995. Teratogenicity of high

vitamin A intake. N. Engl. J. Med. 333, 1369-1373.

Sariola, H. and Sainio, K., 1997. The tip-top branching ureter. Curr. Opin. Cell. Biol. 9, 877–884.

Saxen, L., 1987. Organogenesis of the Kidney. Cambridge: Cambridge University Press.

Schuchardt, A., D’Agati, V., Larsson-Blomberg, L., Costantini, F. and Pachnis, V., 1994. Defects in the kidney and

enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature. 367, 380–383.

Stark, K., Vainio, S., Vassileva, G. and McMahon, A.P., 1994. Epithelial transformation of metanephric mesenchyme

in the developing kidney regulated by Wnt-4. Nature. 372, 679–683.

Published

2012-08-29

How to Cite

Geeta Devi, L. ., Dev Singh, N. ., Singh Banga, H. ., & Dattatray Gadhave, P. . (2012). A concomitant case of unilateral renal agenesis and unihorn uterus in a balb/c mouse. Scientific Journal of Zoology, 1(1), 23-25. Retrieved from http://sjournals.com/index.php/sjz/article/view/1189

Issue

Section

Short Communication