Assessment of essential trace metals (iron, copper and selenium) and heavy metal (lead) in obese diabetics (type 2 diabetic) patients
Keywords:
Obesity, Trace metal, Heavy Metal, Diabetes MellitusAbstract
It is evident that the metabolism of some trace metals is altered in diabetes mellitus and these micronutrients may have specific roles in the pathogenesis and progression of the disease. The aim of this study was to determine the status of trace elements; iron, copper, selenium and lead in obese diabetic patients. Method: The study was carried out on two hundred and four (204) subjects, aged 20-68yrs which comprised of fifty nine (59) obese diabetic subjects, forty five (45) obese non-diabetic patients, forty (40) non-obese diabetic patients and sixty (60) non-obese non-diabetics (apparently healthy volunteers) as control. The trace metals (Fe, Cu, Se and Pb) studied were analyzed using atomic absorption spectrophotometer. Results: The mean levels of Se and Pb were decreased significantly when obese diabetics were compared with control. The Se level was also decreased significantly when obese diabetic was compared with each of obese non diabetic and non obese diabetic. The mean levels of other trace metals studied were decreased when obese diabetics were compared with non obese non diabetics (normal control) although not significant. Values in obese only (OND) subjects were higher than even the controls but this decreased with complication-diabetes mellitus although not statistically significant. In the obese diabetic group, Cu and Se negatively correlated with BMI and this was significant. All trace metals studied significantly correlated positively with BMI in both obese only (OND) and control groups. Conclusion: this study showed that essential trace elements (Fe, Cu and Se) and the toxic trace metal Pb studied were depleted in obese diabetics. It is therefore recommended that Fe, Cu and Se supplementation and therapeutic strategies that will enhance Fe, Cu and Se availability in the body been instituted in obese diabetics.
References
Ariola,O.G; and Idonije, O.B (2009). Status of plasma nitric oxide and non enzymatic antioxidants before and after antipsychotic treatment in Nigeria patients with Schizophrenia. Journal of Research in Medical Sciences, vol. 14:1, 37-42
Arinola Ganiyu, Idonije Blessing, Kehinde Akinlade and Olabisi Ihenyen (2010). Essential trace metals and heavy metals in newly diagnosed schizophrenic patients and those on antipsychotic medication. Journal of Research in Medical Sciences, vol. 15:5, 245-249
Babalola, O.O., Ojo, L.O. and Akinleye, A.O. (2007): Status of the levels of lead and selected
trace elements in type 2 diabetes mellitus patients in Abeokuta, Nigeria. African Jounal of
Biochemical Resources 1:127-131.
Beard, J.L., Dawson, H. and Pinro, D.J. (1996) : Iron Metabolism: a Comprehensive Review.
Nutrition Review. 54 (10): 295-317.
Beytut, E. and Akasakal, M. (2003): Effects of dietary vitamin E and selenium on antioxidant defense mechanisms in the liver of rats treated with high doses of glucocorticoid. Biol. Lem Res. pp. 9131-9241.
Bothwell, T.H. (1999): Overview and Mechanisms of iron regulation. Nutrition Review. 54 (10):
: 237-245.
Burt, R.K. (2007): Autologous non myeloablative hematopoietic stem cell Nutrition Review. 84 (4): 110-114.
Evans, J.L., Maddux, B.A. and Goldfine, I.D. (2005): The molecular basis for Examination Survey (NHANES III). www.cdc.gov . Retrieved 03-04-2012.
Gramm, H.J., Kapft, A. and Bratter, P. (1995): The necessity of selenium, pp. 60- 68.
Idonije O.B; Okogun G.R.A; Iribhogbe O.I, Ekhator C.N; Tijani T.T, Salimon A.Z and
Omonrogieva O (2011a). Serum trace metal levels in diabetic patients attending a tertiary health
centre in Nigeria. Academia Arena, Vol. 3 (7): 28-31
Idonije B.O; Iribhogbe I.O. Okogun G.R.A (2011b). Serum Trace Element Levels in Sickle cell
Disease Patients in an Urban City in Nigeria. Nature and Science, 9 (3), 67-71
Jehn, M., Clark, J. and Guallar, E. (2004): Serum ferritin and risk of metabolic syndrome in U.S.
adults. Diabetes care. 27: 2422-2428.
Kuhn, L.C. (1998): Iron and gene expression: molecular mechanisms regulating cellular iron
homeostasis. Nutrition Review. 56: 11-19.
Lin, J.L., Lin-Tan, D.T., Hsu, K.H. and Yu, C.C. (2003): Environmental lead exposure and progression of chronic renal diseases in patients Without diabetes. English Journal of Medicine. 348(4): 277-286.
Medvei, H. and Victor, C. (1993): The history of clinical endocrinology. Carnforth, Lancs., U.K:
Parthenon Pub. Group. pp. 23–34.
Mueller, A.S. (2006): Selenium, an ambivalent factor in diabetes? established facts, recent findings and perspectives. Current Nutrition of Food Science. 2: 151-154.
Mueller, A.S., Klomann, S.D., Wolf, N.M., Schneider, S., Schmidt, R., Spielmann, J.S., Stangl, G., Eder, K. and Pallauf, J. (2008): Redox Regulation of proteintyrosine phosphatase 1B by manipulation of dietary selenium affects the triglyceride concentration in rat liver. J. Nutr. 138(12): 2328-2336.
Pallauf, J.C., Rivas-Gonzalo, M.D., Castillo, M.P. and Cano, P.T. (2008): of the antioxidant composition of strawberry tree(Arbutus unedo L.) fruits, Journal for Food Compostion 21: 273-281.
Schwartz, G.G. and Reis, I.M. (2000): Is cadmium a cause of human pancreatic transplantation in newly diagnosed type 1 diabetes mellitus. Journal of American Medical Association, Trace Element of Medical Biology. 9: 1-12.
Sjogren, A., Edvinsson , L., Flore'n, C. and Abdulla, M. (1986): Zinc and copper in striated muscle and body fluids from subjects with diabetes mellitus type I. substitutiion in total parenteral nutrition and artificial alimentation pp. 1232-1237.
Thomson, C.D. (2004): Assessment of requirements for selenium and adequacy of selenium
status: a review. European Journal of Clinical Nutrition 58:391-402.
Tsaih, S.W., Korrick, S.I., Schwartz, S., Amarasiriwardena, C., Aro, A., Sparrow, D. and Hu, H. (2004): Lead, diabetes, hypertension, and renal function: The normative aging study. Environ. Health Perspect. 112(11): 178- 1182.
Wedeen, R.P., Maesaka, J.K., Weiner, B., Lipat, G.A., Lyons, M.M. and Vitale, L.F. (1975): Occupational lead nephropathy. Am. Med. 59(5): 630-641.
West, I.C. (2000). Radicals and oxidative stress in diabetes. Diabetic Medicine 17: 171-180.
World HealthOrganization. www.who.int. (2006): http://www.who.int/diabetes/ publications/Definition%20and%20diagnosis%20of%20diabetes_new.pdf. Retrieved 2011-02-20.
Zargar, A.H., Shah, N.A. and Masoodi, S.R. (2002): Copper, zinc and magnesium levels in type-2 diabetes mellitus. Saudi Medical Journal 23:539–542.
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