Open Access Open Access  Restricted Access Subscription Access
Cover Image

The effects of chlorsulfuron and feed containing ascorbic acid on some serum parameters in albino rabbits

Ahmet UZATICI, Baver COŞKUN, Kemal ÇELİK, Can DUMAN

Abstract


As all around the world, pesticides are used in our country to control the harmful organisms. As is known, however, use of pesticides takes a toll on humans, animals and the environment health-wise, and insensible and intensive use causes residues in food, soil, water and air. Even though the use of pesticides creates an increase in quantity product-wise, they are potential toxic materials for humans and animals. In this research, New Zealand albino rabbits (75 days old, 2 kg average live weight) were given chlorsulfuron and vitamin C through feed for 45 days, their liver enzyme activities were monitored and it was checked whether or not the liver was damaged. In the research, levels of GGT and ALK.P in the serum samples received from trial group animals were observed to be sensible in comparison to the control group (P<0.05).


References


Ambali, S.D., Akanbi, N., Igbokwe, M., Shittu, M. ,Kawu, J., 2007. Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C. J. Toxicol. Sci., 32(2), 11-20.

Bendich, A.L., Machlin, J., Scandurra, O., Burton, G.W., Wayner, D.D.M., 1986. The antioxidant role of vitamin C. Adv. Free Rad. Biol. Med., (2), 419-444.

Bhatnagar, P., Scarborough, P., Wickramasinghe, K ., 2011. Trends in the burden of cardiovasculer dieases in the UK,1University of Oxford, Rosemary Rue Building, Old Road Campus Headington, Oxford OX3 7LF.

Biri, H., Ozturk, H.S., Buyukkocak, S., Kaçmaz, M., Cimen, M.Y., 1998. Antioxidant defense potential of rabbit renal tissues after ESWL,Protective effects of antioxidant vitamins. Nephron, 79 (2), 181-185.

Campisi, A., Di Giacomo, C., Russo, A., Sorrenti, V. ,Vanella, G.,1999. Antioxidant system in rat lens as a function of age, Effect of chronic administration of vitamin E and ascorbate. Aging, (11), 39-43.

Chatterjee, I.B., Anuradaha, N., 1991. Ascorbic acid, A Scavenger of oxy radical. Indian J. Biochem. Biophy., (28), 233-236.

Durmusoglu, E., Tiryaki, O., Canhilal, R., 2008. In Turkey Pesticide Usage residue and Durability Issues.

Gokalp, O., Mollaoglu, O., Yılmaz, R.H., Altuntas, I., 2003. The effect of organophosphate insecticide Fenthion rat amylase and lipase enzymes the role of vitamin E and C , the SDU. J. Facul. Med., 10 (2), 21-23.

Flanagan, R.J., Ruprah, M., Meredith, T.J., Ramsey, J.D., 2007. An introduction to the clinical toxicology of volatile substances Drug Safet., 5(5), 359-83.

Inofers, H., Sies, H., 1988.The production by ascorbate and glutathione against microsomal lipid peroxidation is in depended on vitamin , Europ. J. Biochem., 174, 353-357.

Jialal, I., Fuller, C.J., 1993. Oxidized LDL and antioxidants. Clin. Cardiol., (16), 1-9.

John, S., Kale, M., Rathore, N., Bhatnagar, D., 2001. Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocyte. J. Nutr. Biochem., 12, 500–504.

Lunec, J., Blake, D., 1990. Oxygen Free Radicals. Their Relevance to Disease Processes. In, The Metabolic and Moleculer Basis of Acquired Disease, London, UK, 189-212.

Ming, Z., Fan, Y., Yang, X., Lautt, W. W., 2006. Synergistic protection by adenosylmethionine with vitamins C and E on liver injuryinduced by thioacetamide in rats. Free Radic. Biol. Med., 40, 617-624.

Mongi, S., Mahfoud, M., Amel, B., Kamel, J., Abdelfattah, F., 2011. Protective effects of vitamin C Protective effects of vitamin C against haematological and biochemical toxicity induced by deltamethrin in male Wistar rats. Ecotoxicol Environ. Saf., 74, 1765-1769.

Morowati, M ., 1997. Inhalation toxicity studies of thimet (phorate) in male Swiss albino mouse, Mus musculus I. Hepatotoxicity , Environmen. Pollut., 99 (3), 283-288.

Morowati, M., 2011. Biochemical and histopathological change in serum creatinine and kidney induce by inhalation of Thimet (Phorate) in male Swiss albino Mouse, Mus musculus Environ. Res., 87, 31-36.

Padungtod, C., Hassold, T.J., Millie, B.S.E., Ryan, L., Savitz, D.A., Christiani, D.C., Xu, X., 1998. Sperm aneuploidy among Chinese pesticide factory workers. Scoring by the FISH method. Am. J. Ind. Med., 36, 230-23.

Prakasam, A., Sethupathy, S., Lalitha, S., 2001. Plasma and RBCs antioksidant status in occupational male pesticide sprayers. Clinica Chimica Acta., 20, 107-112 .

Stoyanovsky, D.A., Darnow, R., Goldman, R.M., Organisciak, D.T., Kapan, E., 1995. Endogenousascorbate regenerates vitamin E in the retina directly and in combination with dihydrolipoic acid , Curr. Eye Res., 14, 181–189.

Sulak, O., Altuntas, I., Karahan, N., Yildirim, B., Akturk, O., H.R., Yilmaz, H.R., Delibas, N., 2005. Nephrotoxicity in rats induced by organophosphate insecticide methidathion and ameliorating effects of vitamins E and C. Pesticide Biochem. Phys., 83, 21-28.

Tiryaki, O., Canhilal, R., Horuz, S., 2010. The use of pesticides and the risks of Erciyes University. Grad. Sch. Nat. and Appl .Sci. J., 26 (2), 154-169.

Uzunhisarcikli, M., Kalender, Y., Dirican, K., Kalender, S., Ogutcu, A., Buyukkomurcu, F ., 2008. Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and E. Pest. Biochem. Phys., 87, 115–122.

Wefers, H., Sies, H., 1988. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E . Institut für Physiologische Chemie I, Universität Düsseldorf, Federal Republic of Germany. Jun 1.174(2), 353-357.

WHO, 1997. Guidelines for poison control. WHO in Collaboration with UNEP and ILO, Geneva, Switzerland.

Yavuz, T., Altuntaş, I., Delibas, N., Yıldırım, B., 2004. Cardiotoxicity in rat induced by methidathion and ameliorating effect of vitamins E and C. Hum. Exp. Toxicol., 23, 323-329.

Yousef, M.I., El-Demerdash, F.M., Kamel, K.I. , Al-Salhen, K.S., 2003. Changes in some hematological and biochemical incides of rabbits induced by isoflavones and cypermethrin. Toxicol., 189, 223-234.


Full Text: PDF

Refbacks

  • There are currently no refbacks.