Antimutagenic activity of rosmarinus officinalis l. By Ames test

Authors

  • A. Tajehmiri Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IRAN
  • M. Ghasemi Department of Microbiology, College of Basic Science, Lahijan Branch, Islamic Azad University, Lahijan, IRAN
  • F. P. Sabet Department of Microbiology, College of Basic Science, Lahijan Branch, Islamic Azad University, Lahijan, IRAN
  • M. M. Chakoosari Department of Microbiology, College of Basic Science, Lahijan Branch, Islamic Azad University, Lahijan, IRAN
  • N. Abdolahzadegan Department of Microbiology, College of Basic Science, Lahijan Branch, Islamic Azad University, Lahijan, IRAN

Keywords:

Rosmarinus officinalis;Salmonella typhimurium TA100, Sodium azide, Ames test

Abstract

Plants are an important source of substanceswhich are claimed to induce anti-inflammatory and antioxidant effects. Rosemary(Rosmarinus officinalis L.) is a medicinal plant that has many uses intraditional medicine. In this study, of R. officinalis leaves extracts werescreened for their antimutagenic activity against sodium azide by Ames test.The results showed that of R. officinalis leaves extracts can inhibit mutagenicagent of sodium azide. Rosemary leaves extracts with the inhibition of 42.92%sodium azide, showed high potential in decreasing mutagenic agent.Antimutagenic activity was increased significantly when there were livermicrosome extract (S9).

References

Chalvo, V.I., Lingbeck, J.M., Kwon, Y.M., Ricke, S.C., 2008. Extracellular antimutagenic activities of selected probiotic Bifidobacterium and Lactobacillus spp. as a function of growth phase. J. Env. Sci. Health Part., B., 43, 193 -198.

Chobba, I.B., Bekir, A., Mansour, R.B., Drira, N., Gharsallah, N., Kadri, A., 2012. In vitro Evaluation of Antimicrobial and Cytotoxic Activities of Rosmarinus officinalis L. (Lamiaceae) Essential Oil Cultivated from South-West Tunisia. J. Appl. Pharmaceut. Sci., 2 (11), 034-039.

Darsanaki, R.K., Parsa Lisar, M., 2014. Antimicrobial Potential of Root, Stalk and Leaves of Rheum Ribes. J. Rep. Pharm. Sci., 3(1), 10-13.

Eva, S.B., Maria, H.T., Attila, H., Csilla, R., Szollosi, V. (2003). Antioxidant effect of various rosemary (Rosmarinus officinalis L.) clones. Acta Biol., 47(1-4), 111-113.

Golshani, Z., Sharifzadeh, A., 2014. Evaluation of antibacterial activity of alcoholic extract of rosemary leaves against pathogenic strains. Zahedan J. Res. Med. Sci., (ZJRMS)., 16(3), 12-15.

Hussain, A.I., Anwar, F., Chatha, S.A.S, Jabbar, A., Mahboob, S., Nigam, P.S., 2010. Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities. Brazil. J. Microbiol., 41, 1070-1078.

Issazadeh, K., Azizollahi Aliabadi, M., Kazemi Darsanaki, R., Khoshkholgh Pahlaviani, M.R.M., 2012. Antimutagenic Activity of Olive Leaf Aqueous Extract by Ames Test. Adv. Stud. Biol., 4, 397-405

Mortelmans, K., Zeiger, E., 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res., 455, 29- 60.

Shams, A., Mehrabian, S., Irian S., 2012. Assessing the antioxidant and anticarcinogenic activities of virgin olive oil and purified olive oil samples treated with light and heat using the Ames test. Int. J. Microbiol.Res., 4, 173-177.

Ong, T., Wong, W., Stwart, J.D., 1986. Chlorophyllin a potent antimutagen against environmental and dietary complex mixture. Nutr. Res., 173, 111-115.

Shoeb, M., 2006. Anticancer agents from medicinal plants. Bangladesh J. Pharmaco., 1, 35-4.

Wang, W., Li, N., Luo, M., Yuangang, Zu., Efferth, T., 2012. Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components. Molecules., 17, 2704-2713.

Published

2014-07-29

How to Cite

Tajehmiri, A. ., Ghasemi, M., P. Sabet, F., M. Chakoosari, M., & Abdolahzadegan, N. . (2014). Antimutagenic activity of rosmarinus officinalis l. By Ames test. Scientific Journal of Pure and Applied Sciences, 3(7), 78-81. Retrieved from http://sjournals.com/index.php/sjpas/article/view/1365

Issue

Vol. 3 No. 7 (2014): July

Section

Original Article

License

Copyright (c) 2014 A. Tajehmiri, M. Ghasemi, F. P. Sabet, M. M. Chakoosari, N. Abdolahzadegan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.