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Retrospective evaluation of Humane brucellosis in the region of Prizren

F. U. Kryeziu, S. A. Abdushi, V. Xh. Kryeziu, F. D. Mazreku, N. Hulaj, T. Gjergji, I. Dedushaj, J. Abrashi


Prizren and its region for years considered an endemic area for brucellosis. The first case occurred in 1980 in Dragash, but subsequently occurred in Prizren and Rahovec.Aim: Epidemiological features of human brucellosis in the Prizren region, its trend and incidence over the years 2003-2012. Material and methods: In this study we have used data from the registration forms of infective disease, epidemiological surveys, and monthly and annual reports of the National Public Health Institute in Prizren. The data are processed and analyzed using descriptive epidemiological method. Results: In the period 2003-2012 are recorded 215 cases of human brucellosis in the region of Prizren. The municipality with the most recorded cases is Prizren with 43.72%, while with less is Malisheva with only 4.19 % of cases. Year with more cases was 2010th.  140 (65.12%) affected cases were male, and 75 (34.88%) cases were female. The most affected age group was 25-44 years with 67 (31.16%) cases, while the age group 0-4 years has been the least affected with only 4 (1.8%) cases. Incidence per 100000 was 5.82, while at the national level was 3.92/100000 (p<0.05), while the states of the EU / EEA report 0,126 on average (p<0.05). Conclusion: Brucellosis is a public health problem in the region of Prizren. The incidence is very high, and this area remains an endemic area for this disease. Recommendations: It’s needed to mobilize the veterinary and public health services to put under the control of brucellosis, and even intent to eliminate it.


Dedushaj I, Humolli I. Brucelloza. In: Universiteti i Prishtinës. Epidemiologjia speciale e sëmundjeve ngjitëse. Prishtinë; 2005, p.293-99

Muçaj S. at al. Përcaktimi i zonave endemike të Brucellozës në Kosovë 1996-2000.PraxisMedica, Prishtinë 47-2:73-82.

European Centre for Disease Prevention and Control. Annual Epidemiological Report 2012. Reporting on 2010 surveillance data and 2011 epidemic intelligence data. Stockholm: ECDC; 2013.

The Center for Food Security and Public Health & Institute for International Cooperation in Animal Biologics. Brucellosis. July 2009. Available. at:

Pappas G. Treatment of brucellosis. BMJ 2008 Mar 29;336 (7646): 678-9. Epub 2008 Mar 5.

Young EJ. Brucella Species. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Disease. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009: chap 226.

Agalar C, Usubutun S, Turkyilmaz R. Ciprofloxacin and rifampicin versus doxycycline and rifampicin in the treatment of brucellosis. Eur J Clin Microbiol Infect Dis. 1999 Aug; 18 (8): 535-8.

Radojcic S. ‘Brucellosis-Epizootilogic and diagnostic challenge’, Veterinarskiglasnik2005; 59 (1-2) 79-87.

Centers for Disease Control and Prevention (CDC). Brucellosis. Available at:

Cvetnic Z. at al. Rasprostranjenost bruceloze u Republici Hrvatskoj s osvrtom na stanje u Bosni i Hercegovini, Croatian Journal of Infection 28:3, 117-123, 2008

Mantovani A. General epidemiological aspects of major zoonoses in the Mediterranean Region. Proceedings of the MZCP/Workshop on Zoonoses Surveillance and Control in the Mediterranean Region; 1998 Mar 30-31; Cephalonia Island, Greece. Athens: WHO Mediterranean Zoonoses Control Centre; 1998. p. 4-7.

Bosilkovski M, Dimzova M, Grozdanovski K. Natural histori of brucellosis in an endemic region in different time periods. Acta Clin Croat. 2009;48:41–6. [PubMed]

Memish Z, Mah MW, Al Mahmoud S, Al Shaalan M, Khan MY. Brucellabacteraemia: clinicalandlaboratoryobservations in 160 patients. J Infect. 2000;40:59–63. doi: 10.1053/jinf.1999.0586. [PubMed] [Cross Ref]

Tasbakan MI, Yamazhan T, Gökengin D, Arda B, Sertpolat M, Ulusoy S, et al. Brucellosis: a retrospective evaluation. Trop Doct. 2003;33:151–3. [PubMed]

Jelastopulu E, BikasCh, Petropoulos CH, Leotsinidis M. Incidence of human brucellosis in rural area in Western Greece after the implementation of a vaccination program against animal brucellosis, BMC Public Health, 2008;

Brucellosis in humans and animals.: WHO guidance. Geneva, World Health Organization, 2005

Corbel M.J. ‘Brucellosis in humans and animals’, by the World Health Organization in collaboration with the Food and Agriculture Organization of the United Nations and World Organization for Animal Health.WHO/CDS/EPR/2006.7

Longo D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson, J.L., Loscalzo, J., eds.,Harrison's Principles of Internal Medicine, 18th edition, McGraw-Hill, 2012.

Recommendations for J ClinPathol. 2010 Jan; 63 (1): 90-2. Epub 2008 May 21.

Pappas G. et al. The new global map of human brucellosis. Lancet Infect Dis. 2006 Feb; 6 (2): 91- 9.

Obradovic Z., Velic R. ‘EpidemiologicalCharacteristicsofBrucellosis in FederationofBosniaandHerzegovina’CroatMed J. 2010 August; 51(4): 345–350.

Bosilkovski M., Krteva L., Dimzova M, VidinicI., Sopova Z., and SpasovskaK., ‘Human Brucellosis in Macedonia - 10 Years of Clinical Experience in Endemic Region’ Croatian Medical Journal. 2010 August; 51(4)327

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