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Effects of aqueous extracts of garlic (Allium sativum) and ginger (Zingiber officiale) on liver function profile in wistar rats

E. E. Daniel, A.B. Adelaiye, A. Lawan, A. Mohammed, J. A. Tende

Abstract


The present study evaluated the effect of Garlic (Allium sativum) and Ginger (Zingiberofficiale) extracts in rats. To achieve this objective,animals were assigned into the following groups as follows: Group 1: Served as control group and received 1ml of distilled water, Group 2: Received 20mg/kg b w of garlic, Group 3: Received 40mg/kg b w of garlic, Group 4: Received 20mg/kg b w of ginger, Group 5: Received 40mg/kg b w of ginger, Group 6: Received garlic 10mg and ginger 10mg/kg b w Group 7: Received garlic 20mg and ginger 20mg/kg b w. All administration was done orally for a period of 28 days. At the end of treatment all animals were sacrificed from all groups and blood samples collected and the serum separated for liver enzymes analysis. The liver tissue was carefully exicised and then subjected to routine histological investigation. The results of  the study showed no statistically significant (p>0.05) difference on the level of serum ALT and AST in the experimental group fed with single and combined doses of garlic and ginger extract when compared to control group. There was also no significant change (p>0.05) on serum level of ALP in the group that received 20 and 40 mg/kg b w of garlic respectively when compared to the control group. However, the serum level of ALP was a statistically significant different (p<0.05) in the groups treated with 20 and 40 mg/kg b w of ginger and its combined doses when compared to their control group. The histological findings showed that the plant extract did not adversely affect the morphology of liver tissues in all groups treated with various doses of garlic and ginger extract at both single and combined doses administered to animals. In conclusion, the observed effect of the extract at both single and combined doses suggests a non toxic and deleterious effect of the plant extract on the liver tissue, hence safe for consumption especially in humans.


References


Banerjee, S.K., Maulik, M., Manchanda, S.C., Dinda, A. K.,Das, T.K., Maulik,S. K., 2001.Garlic-induced alteration in rat liver and kidney Morphology and associated changes inendogenous antioxidant status.Food ChemToxicol.39, 793-7.

Borek, C., 2006. Garlic reduces dementia and heart-disease risk. Journal of Nutrition; 136 (3),810-812.

Duncan, R.C., Knapp, R. G.,Miller, M. C., 1977. Test of hypothesis in population meansIntroductory Biostatistics for the health sciences. John Wiley and Sons Inc. NY.71-96.

Galozhger, A.E., Kocloff, E. N., 1971.Essential Practical Microtechnique. 2ndEdn.,Lee andFebizer, Philadelphia, pp: 77.

Govindarajan, V.S., 1982. Ginger: Chemistry, technology and quality evaluation (Part I). CritRev Food Sci Nutr.17, 1.

James, M.E., Nannapaneni, R., Johnson, M.G., 1999. Identification and characterization of twobacteriocin producing bacteria isolated from garlic and ginger root. J Food Prot. 62, 899.

Kiuchi, F., Iwakami, S.,Shibuya, M., Hanaoka, F., Sankawa, U., 1992.Inhibition of prostaglandinand leukotriene biosynthesis by gingerols and diarylheptanoids.Chem

Kobayashi, M., Tshida, Y., Shoji, N., Okizumi, Y., 1988.Cardiotonic action of gingerol, anactivator of the Ca++ pumping adenosine triphosphataseofsarcoplasmicreticulum,in guinea pig atrial muscle. J PharmacolExpTher.246, 667.

Miller, K.L., Liebowitz, R.S., Newby,L.K., 2004. Complementary and alternative medicine incardiovascular disease: a review of biologically based approaches. Am Heart J. 147, 401411.

Moyers, S., 1996. Garlic in Health, History and World Cuisine. Suncoast Press, St. Petersburg,FL:1–36.

Qureshi, S., Shah, A.H., Tariq, M., Ageel, A.M., 1989. Studies on herbal aphrodisiacs used in Arab system of medicine.Am J Chin Med. 17, 57-63.

Rhiouania, H., El-Hilalya, J., Israili, Z.H., Lyoussia, B., 2008. Acute and subchronic toxicity ofan aqueous extract of the leaves of Herniariaglabrain rodents. J. Ethnopharmacol. 118,378-386.


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