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The histopathological effects of salvia officinalis on the kidney and liver of rats

A. D. Adekomi, T.D. Adeniyi, A.M. Afodun, K.K. Quadri

Abstract


The aim of this investigationwas to evaluate some of the effects of aqueous leaf extract of Salvia officinalis on the kidney and liver of male Sprague Dawley rats. Ten Sprague-Dawley rats (7-11 weeks old)were randomly assigned into two groups; A and B. Aqueous extract of S.officinalis leaves (300 mg/kg body weight) was administered orally to therats in group B while the rats in group A received equal volume of normalsaline for 14d. At termination of treatment, the histopathology of the kidneyand liver were assessed. The kidney and the liver in the extract treated ratdisplayed organized and preserved histological profile. Our findings suggestthat S. officinalis has no deleterious effects on the kidney and liverof the rats.

References


Katzung, B.G., 2005. Basic and Clinical Pharmacology. 9th Edition, McGraw Hill Medical, New York.

Bruneton, J., 1993. Plantes Médicinales: Phytochimie, Pharmacognosie. 2 éme Ed. Lavoisier, New York.

Fola, A., 1993. Local medicinal plants and the health of the consumers. A paper delivered at the PSN/CF PCON organization workshop: in Clinical Pharmacy and Herbal Medicine. 9, 28-31.

Agbor, A.G., Ngogang, Y.J., 2005. Toxicity of herbal preparations. Cam. J. Ethnobot. 1, 23-28.

Agbor, A.G., Oben, J.E., Ngogang, J.Y., 2005. Haematinic activity of Hibiscus cannabinus. Afr. J. Biotechnol. 4 (8), 833-837.

Prosper-Cabral et. al., 2007. Phytochemical Studies and Antioxidant Properties of Four Medicinal Plants Used in Cameroon. Afr. J. Trad. CAM 4 (4), 495 – 500.

Perry, N., Howes, M.J., Houghton, P., Perry, E., 2000. Why sage may be a wise remedy: effects of Salvia on the nervous system. In: Kintzios, S. (Ed.), In Sage. The Genus Salvia. Harwood Academic, The Netherlands, pp, 207– 232.

Perry, N., Bollen, C., Perry, E.K., Ballard, C., 2003. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacology, Biochemistry and Behavior 75, 651– 659.

Savelev, S.U., Okello, E.J., Perry, E.K., 2004. Butyryl-andacetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents. Phytotherapy Research 18, 315–324.

Bartram, T., 1995. Encyclopaedia of Herbal Medicine, firsted.Grace Publishers, London.

Kuang, P., Xiang, J., 1994. Effect of radix Salviae miltiorrhiza on EAA a dIAA during cerebral ischemia in gerbils: a microdialysis study. Journal of Traditional Chinese Medicine 14, 45–50.

Moretti, M.D.L., Satta, M., Peana, A.T., 1997. A study on antiinflammatory and peripheral analgesic action of Salvia sclarea oil and its main components. Journal of Essential Oil Research 9, 199–204.

Zupko, I., Hohmann, R., Falkay, G., Janicsak, G., Mathe, I., 2001. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme independent system of lipid peroxidation and their phenolic constituents. Planta Medica 67, 366–368.

Clebsch, B., Carol, D.B., 2003. The New Book of Salvias. Timber Press, pp, 216, ISBN 9780881925609.

The Herb Society of America; New Encyclopedia of Herbs & Their Uses, Deni Bown, New York: DK, 2001.

National Institute of Health Guide for the Care and Use of Laboratory Animals: DHEW Publication (NIH), revised, Office of Science and Health Reports, DRR/NIH, Bethesda, USA, 1985.

Adekomi, D.A., 2010. Madagascar periwinkle (Catharanthus roseus) Enhances Kidney and Liver Functions in Wistar Rats. Eur. J. Anat. 14, 111-119.

Yakubu, M.T., Akanji, M.A., Oladiji, A.T., Olatinwo, A.O., Adesokan, A.A., Yakubu, M,O., et al., 2008. Effect of Cnidoscolous aconitifolius (Miller) I.M. Johnston leaf extract on reproductive hormones of female rats. Iran J Reprod Med, 6,149–55.

Carleton, H., 1967. Carleton’s histological technique. Oxford University Press, 4th Ed, pp. 33-280.

Farber, J.L., Chein, K.R., Mittnacht, S., 1981. The pathogenesis of Irreversible cell injury in ischemia; Amer. J. Pathol. 102, 271-281.

Guyton, A., Hall, J., 1996. Textbook of Medical Physiology, Philadelphia: WB Saunders Co.

Stevens, A., Lowe, J., 2005. Human Histology; Chapter 12, p. 232. 3rd ed. Philadelphia: Elsevier Mosby. ISBN 0-3230-3663-5.

Dapar, L.P.M., Aguiyi, C.J., Wannang, N.N., Gyang, S.S., Tanko, M.N., 2007. The Histopathologic Effects of Securidaca longepedunculata on Heart, Liver, Kidney and Lungs of Rats. Afr. J. Biotechnol. 6 (5), 591-595

Ito, U., Sparts, M., Walker, J.R., Warzo, I., Experimental Cerebral Ischemia in Magolian Gerbils (1). Light microscope observations. Acta Neurophatology. USA. 32, 209-223.

Waters, C.M., 1994. Glutamate induced apoptosis of striatal cells in rodent model for Parkinsonism. Neuroscience. 63, 1-5.


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