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Malignant solid tumors in basra pediatric oncology center

Lamya'a J. Dawood, Janan G. Hasan, Hussam M. Salah


Malignant solid tumors represent about 50% of all malignant neoplasm in children aged less than 15 years  ,They make more than  80% of all malignancies in  infants. To focus on clinical and biological characteristics of patients with various types of malignant solid tumors who have been admitted to the Oncology center at Basra Maternity and Children Hospital during the period from the 1st of January 2004 till  the end of December 2009. A retrospective study was carried out at Basra Maternity and Children Hospital during the period from the 1st of January 2004 till  the end of December 2009.Total cases of  cancer admitted to the Center during that period were 704 cases, malignant Solid tumors represented 27.5% of total cases(194 cases). One hundred sixty five patients were included in the study, their age ranged from one month to 14 years, 85 males and 80 females. Sympathetic nervous system tumors represented the highest percentage (35.8%) followed by renal tumors (26.1%), soft tissue sarcomas (18.2%), germ cell tumors (10.3%), retinoblastoma (6.7%) and the least percentage was for hepatic tumors (3%) .  The highest frequency of malignant solid tumors was found in the age group of (1-4years), that  included 79 patient (47.9%), most of them had neuroblastoma ;32 patients (40%).  Most cases with malignant solid tumors were from the center and northern areas of Basra (28.5%,14.6% respectively) and to a lesser extent in western (10.3%), southern (6%), and eastern areas( 1.2%). Other governorates like ThiQar and Maysan account for high rates (21.8%,16.4% respectively) of admissions in Basra pediatric oncology center. The overall mortality was 27.3% (45 cases), it ranged from 11.8%-40%, and most common cause of death was advanced metastatic disease. Non compliance or discontinuation of treatment is an important dilemma for all types of cancer. This study revealed that sympathetic nervous system tumors, the commonest of them was neuroblastoma , most cases presented in stage III or stage IV of the disease. So Improving the diagnostic facilities in Basra Oncology Center by introducing specific type of investigation for evaluation of patient with malignant solid tumors like metaiodobenzylguanidine (MIBG) scan, positron emission tomography (PET), genetic study, and other important biochemical investigations  could assign the patient risk group, and not depending only on simple criteria for the classification of the disease .


Gurney, J.G., Bondy, M.L., 2006. Epidemiology of childhood cancer. In, Pizzo PA, Poplack DG(eds). Principles and practice of pediatric oncology. 5th ed. Philadelphia. Lipp. Will. Wilkins., 1-14.

Memon, F., Al Rathi, S.L., Memon, M.H., 2007. Pattern of pediatric malignant neoplasm at Lumhs, Jamshoro, Pakistan. J. Ayub Med. College Abbottabad., 19(4), 55-57.

Kachanov, D.Y., Dobrenkov, K.V., Shamanskaya, T.V., et al., 2008. Solid tumors of young children in Moscow region of Russian Federation. Rad. Oncol., 42(1), 39-44.

Ekenze, S.O., Ekwunife, H., Eze, B.I., et al., 2010. The burden of pediatric malignant solid tumors in a developing country. J. Trop. Pediatr., 56(2), 111-114.

Dome, J.S., Galindo, C.R., Spunt, S.L., et al., 2004. Pediatric solid tumors. In, Abeloff MD, Aemitage JO, Nrederhuber JE, Kastan MB, McKenna WG(eds). Abeloff's clinical oncology. 3rd ed. Philadelphia. Church. Liv., 2661-2722.

Park, J.R., Eggert, A., Caron, H., 2010. Neuroblastoma, biology, prognosis, and treatment. Hematology and oncol. clin. North Amer., 24,65-86.

Brodeur, G.M., Maris, J.M., 2006. Neuroblastoma. In, Pizzo PA, Poplack DG(eds). Principles and practice of pediatric oncology. 5th ed. Philadelphia. Lipp. William Wilk., 933-970.

Vujanic, G.M., Sandstedt B., 2010. The pathology of wilms' tumor(nephroblastoma). J. clin.pathol., 63, 102-109.

Breslow, N., Olshan, A., Beckwith, J.B., et al., 1993. Epidemiology of wilms' tumor. Med. Pediatr. Oncol., 21,172-181.

Pappo, A.S., Pratt, C.B., 1997. Soft tissue sarcomas in children. Cancer Treatm. Res., 91, 205-222.

Weiss, S.W., Goldblum, J.R., 2001. Enzinger and Weiss's Soft Tissue Tumors. 4th ed. St. Louis, Mo, Mosby.

Wexler, L.H., Meyer, W.H., Helman, L.J., 2006. Rhabdomyosarcoma and the undifferentiated sarcoma. In, Pizzo PA, Poplack DG,(eds). Principles and practice of pediatric oncology.5thed. Philadelphia.Lipp. Will. Wilk., 971-1001.

Cushing, B., Perlman, E.J., Marina, N.M., et al., 2006. Germ Cell Tumors. In, Pizzo PA, Poplack DG,(eds). Principles and practice of pediatric oncology.5thed.Philadelphia.Lipp. Will. Wilk., 1116-1138.

De Aguirre Neto, J.C., Antoneli, C.B., Ribeiro, K.B., et al., 2007. Retinoblastoma in children older than 5 years of age. Pediatr. Blood Cancer., 48 (3), 292-295.

Litten, J.B., Tomlinson, G.E., 2008. Liver tumors in children. Oncolog., 13,812-820.

Habib, O.S., AL-Ali, J.K., AlWiswasi, M., et al., 2007. Cancer registration in Basrah 2005, Preliminary results. Asian Pacif. J. Cancer Prevent., 8, 187-190.

Usmani, G.N., 2001. Pediatric oncology in the 3rd world. Current Opin. Pediatr., 13,1–9.

El-Hayek, M., Trad, O., Donner, M., et al., 2003. Pediatric oncology in the United Arab Emirates, the Tawam hospital experience. Med. Pediatr. Oncol. 41,486-487.

Tanko, N.M., Echejoh, G.O., Manasseh, N.A., et al., 2009. Pediatric solid tumors in Nigerian children, A changing pattern. African J. Pediatr. Surg., 6(1),7-10.

Desandes, E., Clavel, J., Berger, C., et al., 2004. Cancer incidence among children in France, 1990-1999. Pediatr. Blood Cancer., 43, 749-757.

Abramson, S.J., Berdon, W.E., Ruzal, S., et al., 1993. Cervical neuroblastoma in eleven infants, a tumor with favorable prognosis- clinical and radiologic(US, CT, MRI) findings. Pediatr. Radiol., 23,253-257.

Ocana, S.J., Miranda, G.G., Mejia Arangure, J.M., et al., 2004. Frequency of cancer in children residing in Mexico City and treated in the hospitals of the Instituto Mexicano del Seguro Social (1996–2001). BMC Cancer., 4(1),1471-2407.

Kusumakumary, P., Ajithkumar, T.V., Ratheesan, K., et al., 1998. Pattern and outcome of neuroblastoma, a 10 year study. Ind. Pediatr., 35, 223-229.

Seyed-Ahadi, M., Tabari, A., Mirshemirani, A., et al., 2007. Wilms’ Tumor, A 10 Year Retrospective Study. Arch. Iran. Med., 10(1),65-69.

Naguib, S.F., El-Haddad, A., EL-Badawy, S.A., et al., 2008. Multidisciplinary Approach to Wilms’ Tumor, A Retrospective Analytical Study of 53 Patients. J. Egypt. Nat. Cancer Institut., 20(4),410-423.

Jaffe, N., Huff, V., 2007. Neoplasms of the kidney. In, Behrman RE, Kliegman RM , Jenson HB(eds). Nelson textbook of pediatrics.18th ed. Philadelphia. WB Saunders Co. 2140-2143.

Hessissen, L., Kanouni, L., Kili, A., et al., 2010. Pediatric Rhabdomyosarcoma in Morocco. Pediatr. Blood Cancer., 54,25–28.

Arif., M., Iqbal, Z., 2009. Zia-ul-Islam. Retinoblastoma in Nwef, Pakistan.J. Ayub med. college Abbottabad., 21(4),60-62.

Abbasoglu, L., Gun, F., Salman, F.T., et al., 2004. Hepatoblastoma in Children. Acta chir. belg., 104, 318-321.

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