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EFFECTIVENESS OF NESTROFT AS A SCREENING TEST FOR THE DETECTION OF β-THALASSEMIA TRAIT.

S. B. Satpute, M. P. Bankar, A. Momin, G. M. Bhoite

Abstract


The present study was carried out to evaluate the effectiveness of NESTROFT as a screening test for β-thalassemia trait. Naked Eye Single Tube Red cell Osmotic Fragility Test [NESTROFT] is an un-cumbersome and inexpensive test for the detection of β-thalassemia. NESTROFT was applied to 150 patients of β-thalassemia trait and 150 normal control samples. The test was successful in detecting 143 subjects with β thalassemia trait, and negative in all 150 control samples. Sensitivity of the test was 95.2% and specificity was 62.6%. Positive predictive value of NESTROFT was 60.5% and Negative predictive value of NESTROFT was 89.0%. NESTROFT is suitable for screening the suspected cases of β-thalassemia trait as it is easy to perform, can be used for field studies, inexpensive and does not require any sophisticated equipments. NESTORFT is found to be singly most cost effective and promising screening test to detect thalassemia heterozygotes.


References


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